Risk of suicide and fatal heart attack immediately following a cancer diagnosis

Public release date: 5-Apr-2012
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Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet

People who are diagnosed with cancer have a markedly increased risk of suicide and cardiovascular death during the period immediately after being given the diagnosis. This has been shown in a new study from Karolinska Institutet in Sweden, published in the prestigious scientific journal The New England Journal of Medicine.

Being diagnosed and living with a life-threatening illness such as cancer inevitably causes great distress and may result in other health problems in addition to the disease itself. Previous studies have shown that cancer patients are at higher risk of suicide and cardiovascular disease, which, up to now, has mainly been ascribed to the emotional strain of living with the potentially fatal disease and the often physically demanding cancer treatment. Newly published data on patients with prostate cancer suggest, however, that being given the diagnosis may, in itself, be associated with a marked increase in the risk of stress-related disease and death.

In this study, published in The New England Journal of Medicine, a team of researchers from Karolinska Institutet and rebro University in Sweden, and the University of Iceland has followed over 6 million Swedes during 1991-2006 to investigate whether the risk of suicide and cardiovascular death increases immediately after a cancer diagnosis. The study is based on the Swedish national population and health registries and includes more than 500 000 people that were diagnosed with cancer during the study period.

All in all, only a small proportion of patients committed suicide immediately after being diagnosed with cancer. However, the suicide risk during the first week following the diagnosis was twelve times higher than in people without cancer. Similarly, the risk of cardiovascular death was six times higher during the first week and three times higher during the first month, after a cancer diagnosis, compared to people without cancer. Risk elevation of both suicide and cardiovascular death decreased rapidly thereafter during the first year after diagnosis. Furthermore, risk elevation was most pronounced in malignancies with a poor prognosis, e.g. lung and pancreatic cancers, and least pronounced in skin cancer.

The fact that the risk elevation was apparent directly after cancer diagnosis, and decreased in magnitude over time, supports the conclusion that the risk increase may be traced to the diagnosis itself rather than the emotional or physical suffering related to progression of the cancer or to its treatment. Neither was the risk elevation explained by previous medical history, as the increased risk was observed both in patients that had previously been admitted for psychiatric or cardiovascular conditions and in those with no such history.

"Both suicide and cardiovascular death can be seen as manifestations of the extreme emotional stress induced by the cancer diagnosis. The results of this study indicate that the mental distress associated with being given a cancer diagnosis may bring about immediate and critical risks to mental and physical health," says Fang Fang, a researcher at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet, who led the study.

In their publication, the researchers suggest that the evident health risks demonstrated in newly diagnosed cancer patients are likely to represent just the tip of the iceberg of mental suffering in this group of patients. This new understanding of the serious consequences of a cancer diagnosis has great implications for the relatives and healthcare personnel of cancer patients.

"Our study may, we hope, lead to improvements in the care of newly diagnosed cancer patients and hopefully diminish the risk of stress-related disease and death," says Fang Fang.

###

Publication: 'Suicide and Cardiovascular Death after a Cancer Diagnosis', Fang Fang, Katja Fall, Murray A. Mittleman, Pr Sparn, Weimin Ye, Hans-Olov Adami & Unnur Valdimarsdttir. New Engl J Med 366;14, 5 April 2012.

For further information, please contact:

Fang Fang, PhD
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
Tel: 08 524 861 31
E-mail: fang.fang@ki.se

Katja Fall, MD, PhD
Clinical Epidemiology and Biostatistics Unit, rebro University Hospital
School of Health and Medical Sciences, rebro University
Tel: +46 (0)19 602 61 32
E-mail: Katja.Fall@orebroll.se

Unnur Valdimarsdttir, Associate Professor
Centre of Public Health Sciences, University of Iceland
Tel: +354 694 83 88
E-mail: unnurav@hi.is

Download images and contact the KI Press Office: http://ki.se/pressroom

More on preventing suicide: http://ki.se/suicideprevention

Karolinska Institutet is one of the world's leading medical universities. It accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country's broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

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Public release date: 5-Apr-2012
[ | E-mail | Share ]

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet

People who are diagnosed with cancer have a markedly increased risk of suicide and cardiovascular death during the period immediately after being given the diagnosis. This has been shown in a new study from Karolinska Institutet in Sweden, published in the prestigious scientific journal The New England Journal of Medicine.

Being diagnosed and living with a life-threatening illness such as cancer inevitably causes great distress and may result in other health problems in addition to the disease itself. Previous studies have shown that cancer patients are at higher risk of suicide and cardiovascular disease, which, up to now, has mainly been ascribed to the emotional strain of living with the potentially fatal disease and the often physically demanding cancer treatment. Newly published data on patients with prostate cancer suggest, however, that being given the diagnosis may, in itself, be associated with a marked increase in the risk of stress-related disease and death.

In this study, published in The New England Journal of Medicine, a team of researchers from Karolinska Institutet and rebro University in Sweden, and the University of Iceland has followed over 6 million Swedes during 1991-2006 to investigate whether the risk of suicide and cardiovascular death increases immediately after a cancer diagnosis. The study is based on the Swedish national population and health registries and includes more than 500 000 people that were diagnosed with cancer during the study period.

All in all, only a small proportion of patients committed suicide immediately after being diagnosed with cancer. However, the suicide risk during the first week following the diagnosis was twelve times higher than in people without cancer. Similarly, the risk of cardiovascular death was six times higher during the first week and three times higher during the first month, after a cancer diagnosis, compared to people without cancer. Risk elevation of both suicide and cardiovascular death decreased rapidly thereafter during the first year after diagnosis. Furthermore, risk elevation was most pronounced in malignancies with a poor prognosis, e.g. lung and pancreatic cancers, and least pronounced in skin cancer.

The fact that the risk elevation was apparent directly after cancer diagnosis, and decreased in magnitude over time, supports the conclusion that the risk increase may be traced to the diagnosis itself rather than the emotional or physical suffering related to progression of the cancer or to its treatment. Neither was the risk elevation explained by previous medical history, as the increased risk was observed both in patients that had previously been admitted for psychiatric or cardiovascular conditions and in those with no such history.

"Both suicide and cardiovascular death can be seen as manifestations of the extreme emotional stress induced by the cancer diagnosis. The results of this study indicate that the mental distress associated with being given a cancer diagnosis may bring about immediate and critical risks to mental and physical health," says Fang Fang, a researcher at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet, who led the study.

In their publication, the researchers suggest that the evident health risks demonstrated in newly diagnosed cancer patients are likely to represent just the tip of the iceberg of mental suffering in this group of patients. This new understanding of the serious consequences of a cancer diagnosis has great implications for the relatives and healthcare personnel of cancer patients.

"Our study may, we hope, lead to improvements in the care of newly diagnosed cancer patients and hopefully diminish the risk of stress-related disease and death," says Fang Fang.

###

Publication: 'Suicide and Cardiovascular Death after a Cancer Diagnosis', Fang Fang, Katja Fall, Murray A. Mittleman, Pr Sparn, Weimin Ye, Hans-Olov Adami & Unnur Valdimarsdttir. New Engl J Med 366;14, 5 April 2012.

For further information, please contact:

Fang Fang, PhD
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
Tel: 08 524 861 31
E-mail: fang.fang@ki.se

Katja Fall, MD, PhD
Clinical Epidemiology and Biostatistics Unit, rebro University Hospital
School of Health and Medical Sciences, rebro University
Tel: +46 (0)19 602 61 32
E-mail: Katja.Fall@orebroll.se

Unnur Valdimarsdttir, Associate Professor
Centre of Public Health Sciences, University of Iceland
Tel: +354 694 83 88
E-mail: unnurav@hi.is

Download images and contact the KI Press Office: http://ki.se/pressroom

More on preventing suicide: http://ki.se/suicideprevention

Karolinska Institutet is one of the world's leading medical universities. It accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country's broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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